Yevrosiyo tibbiyot va tabiiy fanlar jurnali

Lung damage usually develops against the background of a long course of rheumatoid arthritis, when manifestations of polyserositis develop: pleuritis, pericarditis, which have a favourable prognosis in most cases. In some cases, patients have changes characteristic of interstitial pneumonia (pneumonitis): dyspnoea, intrusive cough, at first dry and then moist, an abundance of fine bubbling and crepitating wheezes. Autoimmune mechanisms play a major role in the pathogenesis of pulmonary involvement in rheumatoid arthritis. In response to nonspecific antigenic influence there is activation of immunocompetent cells of pulmonary interstitium.

Gastroesophageal reflux disease (GERD) is a complex condition characterized by the backward flow of refluxate into the esophagus. Despite its prevalence and frequent clinical diagnosis, the pathogenesis of GERD is multifaceted. Many patients continue to experience persistent symptoms of GERD even after extended treatment with proton pump inhibitors (PPIs) for acid suppression. The development of GERD involves a dynamic interaction of chemical, mechanical, psychological, and neurological factors, all of which influence symptom manifestation, diagnosis, and treatment approaches. Consequently, GERD should be considered a condition that extends beyond simple acid reflux. This review will explore the key contributors to GERD pathogenesis, including aspects related to the refluxate, esophageal defense mechanisms, and factors that facilitate pathological reflux into the esophagus. Additionally, this paper will discuss recent therapeutic advancements and highlight potential future research directions in the management of GERD.

Qandli diabetdagi kardiyomiyopatiya (DM) yurak mushaklaridagi strukturaviy va funktsional o'zgarishlar bilan tavsiflangan murakkab kasallikdir. Kasallikning ikkinchi bosqichida progressiv o'zgarishlar, shu jumladan miyokard gipertrofiyasi, fibroz va energiya almashinuvining buzilishi kuzatiladi. Ushbu maqolada diabetning 2-bosqichida kardiyomiyopatiyaning rivojlanish mexanizmlari, giperglikemiya, oksidlovchi stress va yallig'lanish jarayonlarining miyokardga ta'siri, shuningdek, diagnostika va davolashning zamonaviy usullari, shu jumladan dori-darmon va dori-darmonlarga qarshi yondashuvlar muhokama qilinadi.

Systemic lupus erythematosus, sometimes known as SLE, is a type of autoimmune illness that can express itself in a dizzying array of different ways in patients. Atherosclerosis and the conditions that result from it are the leading causes of late mortality in people who have complications from SLE. Traditional risk factors, the presence of specific risk factors, the duration of the course, the use of glucocorticoids (GC), the presence of autoantibodies to double-stranded (native) DNA, and the presence of antiphospholipid antibodies all create conditions that accelerate the development of atherosclerosis in this group of patients. The research that is now available suggests that established risk factors for cardiovascular disease should be revised in order to take into consideration the beneficial effect of antimalarial medications as well as the unfavorable prognostic effect of prolonged use of GC.

Лапароскопическая холецистэктомия является широко используемым малоинвазивным методом хирургического лечения, особенно у пожилых пациентов. Однако необходимость карбоксипневмоперитонеума и механической вентиляции создает значительные гемодинамические и дыхательные проблемы. В данном исследовании сравнивается эффект комбинированной мультимодальной анестезии (эпидуральная блокада с механической вентиляцией) и традиционной тотальной внутривенной анестезии с механической вентиляцией у пожилых пациентов (60-74 года). Анализируя интраоперационную и послеоперационную гемодинамическую стабильность, дыхательную функцию и результаты обезболивания, данное исследование направлено на определение оптимального анестезиологического подхода для повышения безопасности и восстановления пациента.

Advances in laparoscopic technology have significantly improved surgical outcomes by reducing operative trauma, enhancing recovery speed, and minimizing postoperative complications. These benefits are particularly crucial for elderly patients, who often have multiple comorbidities affecting perioperative management. Laparoscopic cholecystectomy is a common minimally invasive procedure, but in elderly patients, it presents challenges due to intraoperative hemodynamic fluctuations caused by pneumoperitoneum and patient positioning. This study aims to compare the effects of combined multimodal anesthesia (CMA) incorporating epidural block with mechanical ventilation versus total intravenous anesthesia (TIVA) on hemodynamic stability in elderly patients. The research analyzes intraoperative cardiovascular parameters, including blood pressure (BP), heart rate (HR), and cardiac output, as well as postoperative recovery markers.

Ushbu maqolada Arslonquyruq o‘simlik yer ustki qismi xomashyosidan quruq ekstrakt olishda erituvchilarni tanlandi,  olingan ekstraktga   tahlil usullarini ishlab chiqildi. Chinligini aniqlashda YUQX tahlil usulini ishlab chiqildi, tarkibidagi flavanoidlarni miqdorini aniqlandi.

Ushbu maqolada O’zbekiston hududlarida keng tarqalib o’sadigan yantoq  (верблюжья колючка) o’simligini hom ashyosidan quruq ekstrakt olishda ekstragentlarni tanlandi,quruq ekstrakt yig’indisi aniqlandi,ekstrakt tarkibidagi moddalarga nisbatan kimyoviy sifat reaksiyalar qilindi va tarkibidagi rutinni miqdori fotoelektrokolrimetriya (FEK) usulida aniqlandi.Chinligini yupqa qatlam xromotografiya (YUQX) usulida aniqlashda organik erituvchilar aralashmalarini (sistema) tanlandi va   15 % sirka kislotada Rf  = 0,56 ±  0,02 qiymati aniqlandi.

This comprehensive observational cohort study meticulously evaluated the effectiveness and safety associated with the combination therapy of adalimumab and methotrexate in individuals diagnosed with the debilitating condition known as rheumatoid arthritis (RA). The participants in this investigation were systematically categorized into three distinct groups, each receiving different treatment regimens. The findings revealed that the synergistic combination of adalimumab and methotrexate demonstrated a statistically significant superiority over methotrexate used as a standalone treatment in achieving clinically meaningful responses, specifically measured by ACR20, ACR50, and ACR70, during a rigorous nine-month treatment period. In this context, Group IB, which was administered a higher dosage of methotrexate, displayed marginally improved rates of clinical improvement compared to Group IA; however, it is worth noting that the difference between these two groups did not reach statistical significance.

Ушбу мақолада тавсия этилаётган «Ситмет» ва «Энформин» таблетка массаларининг технологик хоссаларини ўрганиш натижалари келтирилган. тадқиқотларда технологик хоссалардан  фракцион таркиб, сочилувчанлик, сочилувчан зичлик, табиий оғиш бурчаги, қолдиқ намлик, прессланиш коэффициенти, прессланувчанлик кабилар ўрганилган ва муқобил таркиб танланган.

Ushbu maqolada biz bo‘g‘im kasalliklari va ularning ba’zi turlari haqidagi ma’lumotlarni to‘pladik. Ular ichidan gonoartroz kasalligi haqida to‘xtalib o‘tdik. Bu kasallikning paydo bo‘lishi va uning davolash usullarining zamonaviy va xalq usulida ham yoritdik.

Ushbu tadqiqotda, soʻnggi yillarda oʻz tadqiqotlarimiz va adabiyot manbalariga asoslanib, nefropatiyalar (irsiy, teratogen, tashqi muhit omillari)ni rivojlanishiga va progressiyasiga taʼsir etuvchi xavf omillari oʻrganildi. Ushbu xavf omillarini vaqtida aniqlash va oddiy profilaktik choralarni (diyeta, suyuqlik rejimi, mikroiqlimni saqlash, infeksion, toksik va allergik taʼsirlardan himoya qilish va dizmetabolizmni tuzatish) qoʻllash orqali nojoʻya oqibatlarning oldini olish mumkin (interstitsial nefrit (IN), siydik tosh kasalligi (STK), ikkilamchi dizmetabolizm (DZM), ikkilamchi piyelonefrit). Tashqi muhit omillari, xususan, bolalarda metabolik buzilishlar mavjud boʻlgan hollarda patologiyaning namoyon boʻlishiga sabab boʻladigan omillar sifatida fasllararo iqlim oʻzgarishlari – past va yuqori haroratlarga moslashish, oziqlanishdagi xatolar, emotsional va jismoniy yuklar, membranopatiyalar va interkurrent kasalliklar keltiriladi. Boshqa tomondan, bola oilasida aniq bir kasalliklarga moyillik mavjudligini (nasl-nasab, meros boʻyicha yuklanganlik indeksi) biokimyoviy, immunologik va funksional tadqiqotlar yordamida aniqlash mumkin. Siydik kislota diatezi boʻlgan nefropatiyalarni oldini olish va metafilaktikasi boʻyicha profilaktik chora-tadbirlar sxemasi ishlab chiqilgan.

Ацикловир – противовирусное средство. Характеризуется прямым действием в отношении вируса. Применяется с лечебно-профилактической целью при различных разновидностях герпетической инфекции. Обладает выраженной, избирательной активностью в отношении вирусов: Herpes simplex типов 1 и 2, Varicella zoster, Эпштейна-Барр, цитомегаловирус. Действие направлено как на лечение (снижается вероятность появления новых элементов, висцеральных осложнений, быстрее формируются корки, уменьшаются боли при опоясывающем лишае), так и на предупреждение рецидивов. Ацикловир является структурным аналогом пуриновых нуклеозидов (нормальные компоненты ДНК). Избирательная противогерпетическая активность обусловлена сродством к тимидинкиназе определенных вирусов, под действием которой и других ферментов активируется (переходит в ацикловиртрифосфат) и препятствует размножению вирусов.

Ишемическая болезнь сердца (ИБС) остается одной из ведущих причин смертности и инвалидности в Узбекистане. В данной статье представлен всесторонний анализ факторов риска ИБС, включая социально-экономические, поведенческие, медицинские и экологические аспекты. На основе анализа более 30 научных статей из PubMed, ScienceDirect, а также исследований узбекских, российских и зарубежных авторов, рассмотрены современные тенденции, выявлены ключевые проблемы и предложены стратегии для улучшения профилактики и лечения ИБС в Узбекистане.

Tuberculosis (TB) remains a significant public health concern, particularly among children and adolescents, who are more vulnerable to severe disease forms and long-term complications. Modern approaches to TB prevention emphasize early diagnosis, vaccination, chemoprophylaxis, and strengthened public health strategies. The Bacillus Calmette-Guérin (BCG) vaccine remains a cornerstone of pediatric TB prevention, but advancements in diagnostic technologies and the development of new vaccine candidates are enhancing protection. Additionally, targeted screening programs and preventive therapy for high-risk populations are proving effective in reducing TB incidence. This article reviews contemporary preventive strategies, highlights innovative interventions, and underscores the importance of global collaboration in eradicating childhood TB.

Latent tuberculosis infection (LTBI) remains a significant global health challenge, contributing to the persistence of active tuberculosis (TB) cases. Early and accurate detection of LTBI is essential for effective TB control strategies, yet current diagnostic methods face substantial limitations. The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are widely used, but both exhibit variable sensitivity, specificity, and logistical constraints, particularly in low-resource settings. Moreover, distinguishing LTBI from active TB and determining the risk of progression to active disease remains an ongoing issue. This article reviews the current diagnostic landscape for LTBI, highlights existing gaps, and explores emerging technologies with the potential to enhance diagnostic accuracy and accessibility. Addressing these challenges is crucial for improving global TB prevention efforts and achieving the goals outlined in the End TB Strategy.

Dyslipidemia, characterized by abnormal lipid profiles, is frequently observed in individuals with chronic obstructive pulmonary disease (COPD). This condition has gained attention due to its potential impact on the progression of COPD and its association with increased cardiovascular morbidity and mortality. The mechanisms linking dyslipidemia to COPD are multifactorial, involving systemic inflammation, oxidative stress, and alterations in lipid metabolism. These changes may exacerbate the underlying pulmonary pathology and contribute to the higher cardiovascular risk seen in COPD patients. This review examines the pathophysiological mechanisms, clinical significance, and potential therapeutic strategies to address dyslipidemia in the context of COPD. Emphasis is placed on the importance of early detection, monitoring of lipid profiles, and the role of lipid-modifying agents in improving patient outcomes.

Bacillus Calmette-Guérin (BCG) vaccination remains a cornerstone in the global strategy for tuberculosis (TB) control, particularly in regions with high TB prevalence. Despite its widespread use, several challenges and complications associated with BCG vaccination have emerged, affecting its efficacy and safety. These include variations in vaccine strain, differences in immunogenic response, and adverse reactions ranging from mild local reactions to more severe, albeit rare, systemic complications. The effectiveness of BCG in preventing pulmonary tuberculosis and its potential role in protecting against other diseases such as bladder cancer and leprosy have sparked ongoing debate. This review explores the key issues surrounding BCG vaccination, including its historical background, current challenges in its application, and the management of associated complications. Special attention is given to the risks and benefits of the vaccine in immunocompromised populations, as well as the global implications for TB control efforts.

Qon aylanish tizimi kasalliklari, jumladan, yurak-qon tomir kasalliklari va insult aholi salomatligining jiddiy muammosi bo‘lib, O‘zbekistondagi barcha o‘lim holatlarining deyarli 47 foizini tashkil qiladi. Bu sharoitlar nafaqat inson salomatligiga, balki katta ijtimoiy va iqtisodiy yuklarni ham yuklaydi. Ushbu tadqiqotning maqsadi ijtimoiy va gigiyenik ahamiyatini baholash va O'zbekistonda kardiologik tibbiy yordamning mavjud tashkil etilishini tahlil qilish, mavjudlik va profilaktika strategiyalariga urg'u berishdan iborat.

Oila shifokorlari birlamchi tibbiy yordam ko‘rsatishda muhim o‘rin tutadi, aholiga qulay va keng qamrovli tibbiy xizmat ko‘rsatadi. O‘zbekistonda aholi salomatligi ko‘rsatkichlarini yaxshilashda oilaviy shifokorlar faoliyati samaradorligini oshirish muhim ahamiyatga ega. Ushbu maqola O‘zbekistondagi birlamchi tibbiy-sanitariya yordami muassasalarida oilaviy shifokorlar faoliyatini optimallashtirish, tibbiy tayyorgarlik, ish yukini taqsimlash va raqamli sog‘liqni saqlash texnologiyalarini integratsiyalash kabi muammolarni hal qilishning asosiy strategiyalarini ko‘rib chiqadi. Maqsadli siyosat islohotlari, salohiyatni oshirish tashabbuslari va bemorga yo'naltirilgan yondashuvlarni amalga oshirish orqali O'zbekiston birlamchi tibbiy yordam tizimi samaradorligini oshirishi mumkin.

Drug-resistant tuberculosis (DR-TB) remains a significant global health challenge, posing serious threats to public health and complicating disease control efforts. The emergence of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has limited the effectiveness of standard treatment regimens, necessitating the development of novel therapeutic approaches and comprehensive management strategies. This article explores the current landscape of DR-TB treatment, highlighting recent advancements in pharmacological therapies, the role of individualized treatment protocols, and the importance of patient-centered care. Additionally, it addresses key barriers to successful treatment outcomes, including delayed diagnosis, treatment adherence issues, and healthcare infrastructure limitations. The article concludes with recommendations for strengthening global TB programs, accelerating research efforts, and enhancing access to innovative treatments to improve patient outcomes and reduce TB transmission.

The increasing prevalence of arterial hypertension among adolescents highlights the need for healthcare professionals to develop specialized skills in managing this condition. Simulation-based training offers an effective educational tool to enhance clinical competence among nursing students.

Me'da yarasiga qarshi, peshob xaydovchi va qon to‘xtatuvchi xossaga ega bo‘lgan yangi dorivor o‘simlik vositasi - tubulg‘ibargli bo‘ymodaron gullarining xavfsizligini baholashda biologik kontaminantlar bo‘lgan aflotoksinlar aniqlandi. Yuqori samarali suyuqlik xromatografiyasi usulida massa-spektrometrik detektori yordamida ma’lum bo’lgan to’rtta aflatoksinlar B₁, B₂, G₁ va G₂ dan faqat bitta aflatoksin B₁ aniqlandi. Tubulg‘ibargli bo‘ymodaron gullari tarkibida  aflatoksinlar miqdori 0,00042 ± 0,00001 mkg/kg ekanligi aniqlandi, bu esa qo’yilgan talablarga to’liq javob beradi (0,005 mkg/kg dan ko’p emas) va o’rganilayotgan xomashyoning xavfsizligidan dalolat beradi.

This article analyzes the negative impacts of climate change on various ecosystems. It is shown that increasing temperatures, changing precipitation patterns, rising sea levels, species migration, and the spread of new diseases pose significant threats to ecosystems. In particular, these impacts are explained with specific examples such as the loss of polar bear habitat, the disruption of food chains due to drought, and the destruction of coral reefs. The article emphasizes that climate change is a serious threat to the stability of global ecosystems and emphasizes the need to take effective measures to address these problems.

The article analyzes data on the general, seasonal and sexual activity of the terrestrial mollusk Xeropicta candaharica. As a result of studying the activity of this species of mollusk in natural and laboratory conditions, the following was determined. The general activity of X. candaharica mollusks in the spring period was observed at air temperatures from +5^oC to +23^oC and relative humidity from 45% to 100%, sexual activity was observed at air temperatures from +5^oC to +19^oC, relative humidity from 55% to 95%, and the egg-laying process was observed at air temperatures from +1^oC to +21^oC, relative humidity from 63% to 90%. The development period of eggs in the natural environment lasted 11-16 days and depended on air temperature. At an average daily air temperature of +12^oC, the eggs developed for 15-16 days, and at +14^oC for 11-13 days. In laboratory conditions, at an average daily air temperature of +15.5^oC, the eggs developed for 18-20 days.

Ushbu maqola qon bosimi (AG) va taxikardiya (YQS>90 d\u) bilan og'rigan homilador ayollarda β-blokatorlarni qo'llash samaradorligini baholashga bag'ishlangan. Preparatning homiladorlik davrida yurak-qon tomir tizimiga ta'sirini xolis baholash uchun Holter-EKG monitoringi va 24 soatlik qon bosimi monitoringi kabi zamonaviy usullaridan foydalanilgan.

This paper examines the role of electronic medical information (EMI) in modern healthcare, as well as security issues related to its use. EMR includes patient health data stored in digital format, which provides improved access to information, reduced errors, and simplified data exchange between medical institutions. However, using EMR is also associated with risks such as data leakage, cyber attacks, and misuse of information.

This study investigates the surgical treatment of bladder exstrophy (BE) in 64 newborns and infants. Researchers compared one-stage cystosphincterourethroplasty with a staged approach starting with cystosphincteroplasty followed by urethroplasty. The staged correction group (18 patients) showed significantly better results, with fewer recurrences of exstrophy and epispadias compared to the one-stage group (46 patients), where recurrence was observed in a notable percentage. The study concludes that a staged surgical approach is the preferred method for treating BE in newborns and infants, leading to more favorable outcomes, except in specific cases for girls.

В нашей работе нами были описаны результаты нашего исследования по реактивности перестройки внутрипеченочных желчных протоков при нарушении оттока желчи.

Toshkent viloyati Bo’stonliq tumanida 2024-yil iyul oyida gullash davrida botanik jihatdan tasdiqlangan o’simlikdan yig‘ib olingan Salvia sclarea L. barglaridan gidrodistillatsiya usuli bilan olingan efir moyining komponent tarkibi o‘rganildi.GX-MS tahlili yordamida efir yog‘ining tarkibida 43 ta birikma aniqlanib, ular umumiy efir moyi‘ miqdorining 95,4% ini tashkil etdi. Tadqiqot natijalariga ko‘ra, olingan yog‘ tarkibidagi monoterpenlar va oksidlangan monoterpenlarning umumiy miqdori mos ravishda 9,04% va 31,6% ni tashkil qilgan, seskviterpenlar va oksidlangan seskviterpenlar esa mos ravishda 3,75% va 7,7% ni tashkil qilgan.

В статье приведены результаты иссследований по определению хорологии и эколого-ценотической приуроченности тысячелистника таволголистного в Узбекистане. На основании данных литературы и флористического каталога Центрального гербария Узбекистана, показано значение растения в экономике природы и его роль в растительных ландшафтах. Установлены мета обитания, участие в покрове ксерофильной древесной и кустарниковой растительности (Xerodenelre и Xerothamna), горных лиственных лесов, кустарников мезофильного склада (Therodendra), арчевников (Arceuthondendra) и высокогорных или субальпийских лугов (Cryomesopoia).

This article discusses acute hematogenous osteomyelitis (AHO) in children, a serious condition involving purulent inflammation of bone marrow and surrounding tissues. It details the challenges in early diagnosis and the importance of timely treatment to prevent complications. The article covers etiology, pathogenesis, classification, clinical presentation, diagnostic methods, and treatment principles. Key aspects include the significance of early surgical intervention, rational anti-inflammatory therapy, and addressing antibiotic-resistant microorganisms to improve outcomes in pediatric patients.

Ushbu ishda maymunjon barglari quruq ekstrakti, qoraqarag’at barglari quruq ekstrakti, qizilmiya ildizi quruq ekstrakti va na’matak mevalari quruq ekstrakti asosida ishlab chiqilgan "Idenol" tabletkasining texnologiyasi taqdim etilgan. Yordamchi moddalar sifatida bog‘lovchi komponent sifatida etil spirt 70%, to’ldiriuvchi va gigroskopiklikka qarshi agent sifatida MKS, shuningdek, tabletkani parchalanishini taminlash maqsadida dezintegrat sifatida natriy kraxmal glikolati ishlatiladi. Ushbu ilmiy ishda bir nechta metodlarning kombinatsiyasi bilan nam granulyatsiya metodi qo‘llanilgan. Olingan tabletkalar talab ko‘rsatkichlarga mosligi tekshirilgan va eng mos keladigan tarkib tanlangan.

Maktab yoshidagi bolalardagi endokrin kasalliklar o'sish, rivojlanish va umumiy farovonlikka uzoq muddatli oqibatlari tufayli sog'liqni saqlashning asosiy muammosiga aylandi. Genetik moyillik, atrof-muhit ta'siri, ovqatlanishning nomutanosibligi va turmush tarzini tanlash kabi omillar endokrin kasalliklar, jumladan, qandli diabet, semirib ketish, hipotiroidizm va o'sish gormoni etishmovchiligining tarqalishiga yordam beradi. Samarali profilaktika strategiyalari orasida erta skrining dasturlari, sog'lom ovqatlanish va jismoniy faollikni targ'ib qiluvchi sog'liqni saqlash tashabbuslari, ota-onalar va o'qituvchilar o'rtasida xabardorlikni oshirish kiradi.Ushbu maqolada bolalarda endokrin kasalliklar bilan bog'liq asosiy xavf omillari ko'rib chiqiladi va so'nggi tadqiqotlar va siyosat tavsiyalari asosida profilaktika choralari muhokama qilinadi.

Maqolada yurak-qon tomir kasalliklari uchun xavf omillari va ushbu patologiyani kamaytirish uchun profilaktika choralari haqida ma’lumotlar keltirilgan. Bolalarda yurak-qon tomir kasalliklari xavf omillarining tarqalishi sog‘liqni saqlashning muhim muammosiga aylandi. Jahon sog‘liqni saqlash tashkiloti ma’lumotlariga ko‘ra, yurak-qon tomir kasalliklarining aksariyati tamaki iste’moli, noto‘g‘ri ovqatlanish va semirish, jismoniy harakatsizlik, spirtli ichimliklarni zararli iste’mol qilish va havoning ifloslanishi kabi xatti-harakatlar va ekologik xavf omillarini bartaraf etish orqali oldini olish mumkin.

55 та янги туғилган чақалоқлар ва уларни ҳомиладорликда анемия билан касалланган оналари текширилди, назорат гуруҳи - 20 та камқонлиги бўлмаган она ва уларнинг болалари.Ҳомиладорликдаги камқонликда уни хомиланинг ривожланишига ва чақалоқларни эрта мослашувига таъсирини аниқлаш мақсадида тадқиқот ўтказилди, хомиладорларни касалликларин турлари ва оғирлик даражаси ўрганилди.Аниқландики, Ҳомиладорликдаги темир танқислигидаги камқонлиги (ТТК) анемия гестацион жараённи кечишини оғирлаштиради, туғруқ ва туғруқдан кейинги даврда кўпгина асоратларга олиб келади, ҳомиланинг ва чақалоқларнинг патологик холатларига сабаб бўлади.Ҳомиладорларнинг ТТК полиэтиологиккасаллик бўлиб, мураккаб патоганезга эга, темир ва фолат кислотатанқислиги, ҳамда бир қатор мухим микроэлементлар дисбаланси натижасида юзага келади.

Yurak ishemik kasalligi (YuIK) butun dunyo bo'ylab bir necha yillar davomida o'limning etakchi sababidir. Alkogolsiz yog'li jigar kasalligi, eng keng tarqalgan jigar patologiyasi, YuIK rivojlanishining xavf omili va o’g’ir prognozning bashoratchisi sifatida qaraladi. Tadqiqotimizning maqsadi alkogolsiz yog'li jigar kasalligi bilan kasallangan va kasallanmagan YuIK bilan og'rigan bemorlarda kardiometabolik parametrlarni solishtirishdir. Tadqiqotga 85 nafar YuIK kasalligi istiqbolli ravishda kiritilgan, ulardan 61 nafari alkogolsiz yog'li jigar kasalligi bo’lgan (I guruh) va 24 nafari alkogolsiz yog'li jigar kasalligi (II guruh) bo'lmagan. Ikkala guruhda ham xavf omillari, antropometrik ko'rsatkichlar, lipidogramma, glikemik profil, exokardiyografik (ExoKG) yurakning strukturaviy-geometrik va koronar kaltsiy ko'rsatkichlari bo'yicha qiyosiy tahlil qilindi. YuIK va alkogolsiz yog'li jigar kasalligi bilan og'rigan bemorlarda umumiy xolesterin, juda past zichlikdagi lipoproteinlar, triglitseridlar, insulin, yurakning strukturaviy ko'rsatkichlari va koronar kaltsiy statistik jihatdan sezilarli darajada yuqori ekanligi aniqlandi. Shunday qilib, YUIK va alkogolsiz yog'li jigar kasalligi o'rtasidagi bog'liqlik ikki tomonlama va jigar kasalliklari yurak-qon tomir kasalliklarini kuchaytirishi mumkin.

Ushbu maqolada Yurak ishemik kasalligi va Gipertoniya kasaliglarining kelib chiqish sabablari to’liqroq yoritildi.  Hozrigi kunda aholimiz o’rtasida ayniqsa,  yoshi 40 yoshdan oshgan insonlarda ushbu kassaliklar ko’p uchramoqda. Yurak ishemik kasalligi va Gipertoniya kasaliklarining kelib chiqishi va rivojlanishiga kishilarning yoshi, kasallikka irsiy moyillik, qandli diabet, , spirtli ichimliklar istemol qilish, chekish, kamharakatlilik va ruhiy hamda jismoniy zo’riqish kabi holatlar sabab bo’lishi mumkin.

This article provides information on medicinal plants used in the treatment and prevention of diabetes, as well as the remedies, formulations, biological active substances, and their technologies derived from these plants. During the research, dozens of local medicinal plant species and their specific characteristics, the properties of their formulations, indications for use, the beneficial properties of medicinal plants and formulations in the treatment of diabetes, and the results of studies on their technological properties are presented.

Диагностика генеза головокружения и в настоящее время – одна из сложнейших задач медицины вследствие большого количества разнообразных по генезу патологий с данным синдромом. В статье приведен обзор литературы последних лет по вопросам распространенности, этиопатогенеза, диагностики, дифференциальной диагностики, лечению и реабилитации вестибулопатий центрального и периферического генеза.