ТИЗИМЛИ ҚИЗИЛ БЎРИЧА БИЛАН КАСАЛЛАНГАН БЕМОРЛАРДА ЛИПИД СПЕКТРИ КЎРСАТКИЧЛАРИНИНГ ЯЛЛИҒЛАНИШ МЕДИАТОРЛАРИ ВА ФИБРИНОГЕН БИЛАН БОҒЛИҚЛИГИ
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Тизимли қизил бўрича (ТҚБ) – асосан аёлларда учрайдиган, аутоиммун характерга эга бўлган яллиғланишли ревматик касаллик ҳисобланади. У умумий яллиғланиш фонида кўплаб ички аъзо ва тўқималарни зарарлайди. Шу билан бирга, ТҚБ билан касалланган беморларда атеросклероз ва кардиоваскуляр асоратлар ривожланиши тезлашади. Бу ҳолатда липид алмашинувининг бузилиши ва яллиғланиш жараёни ўртасидаги ўзаро боғлиқлик муҳим ўрин тутади. Ушбу мақолада тизимли қизил бўрича (ТҚБ) билан касалланган беморларда липид алмашинуви бузилишлари ва яллиғланиш жараёни ўртасидаги ўзаро боғлиқлик таҳлил қилинади. Хусусан, липид спектри кўрсаткичлари – умумий холестерин, триглицеридлар, юқори ва паст зичликдаги липопротеидлар билан C-реактив оқсил, церулоплазмин ва фибриноген каби ўткир фазали яллиғланиш оқсиллари ўртасидаги корреляция кўриб чиқилади. Мавжуд клиник ва биокимёвий тадқиқотлар таҳлили орқали мазкур кўрсаткичларнинг аҳамияти ва уларни прогностик маркер сифатида қўллаш имкониятлари муҳокама қилинади.
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