QANDLI DABETNING GENETIK ASPEKTLARI

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Abstrak:

Genom bo'yicha o'tkazilgan tadqiqot natijalarining deyarli to'rtdan biri endokrinologik kasalliklar va ularning xususiyatlari bilan bog'liq. Ushbu kashfiyotlar hali klinik yordamga jiddiy ta'sir ko'rsatmagan bo'lsa-da, genetika ertangi kunning dori maqsadlarini ta'minlash orqali katta ta'sir ko'rsatadi, eksperimental va bioinformatika yutuqlari gen kashfiyotida dori ishlab chiqarishgacha bo'lgan vaqtni qisqartiradi. Umumiy endokrin kasallikning kichik turi uchun genetik ma'lumotlardan foydalanish, aniqrog aytganda ularni oldini olish va davolash imkonini beradi. Kelajakdagi yutuqlar bizga DNKning harflar qatori sifatidagi an'anaviy ko'rinishidan uzoqlashishga imkon beradi, bu bizga "yo'qolgan merosxo'rlik" ning ko'p qismini tushuntirib beradigan yuqori tartibli tuzilmani o'rganishga imkon beradi.

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Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y: A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. N Engl J Med 342:301, 2000.

Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661, 2007.

Todd JA, Walker NM, Cooper JD et al.: Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39:857, 2007.

Jones EY, Fugger L, Strominger JL, Siebold С: MHC class II proteins and disease: a structural perspective. Nat Rev Immunol 6:271,2006.

Park Y: Functional evaluation of the type 1 diabetes (T1D) susceptibility genes. Diabetes Res Clin Pract 77 Suppl 1:S110, 2007.

Chistiakov et al.: The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies. Immunol Lett 118:1,2008.

Frayling TM: Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 8:657, 2007.

Zeggini E et al.: Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008.

Babenko AP et al.: Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N Engl J Med 355:456, 2006.

Gloyn AL et al.: Activating mutations in the gene encoding the ATPsensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 350:1838, 2004.

Murphy R et al.: Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation. Diabet Med 2008.

Stoy J et al.: Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Nat Acad Sci USA 104:15040, 2007.

Liu N, Huang R, Baldacchino T, Sud A, Sud K, Khadra M, et al. Telehealth for noncritical patients with chronic diseases during the COVID-19 pandemic. J Med Internet Res 2020 Aug 07;22(8):e1949

Singh AK, Gupta R, Ghosh A, Misra A. Diabetes in COVID-19: prevalence, pathophysiology, prognosis and practical considerations. Diabetes Metab Syndr 2020;14(4):303-310

Al-Shamsi HO, Alhazzani W, Alhuraiji A, Coomes EA, Chemaly RF, Almuhanna M, et al. A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group. Oncologist 2020 Jun;25(6):e936-e945.

Nouri S, Khoong EC, Lyles CR, Karliner L. Addressing equity in telemedicine for chronic disease management during the Covid-19 pandemic. NEJM Catalyst 2020 May 04;1(3):1-13

Katzow MW, Steinway C, Jan S. Telemedicine and Health Disparities During COVID-19. Pediatrics 2020 Aug;146(2):e20201586