OPTIMIZATION OF OUTCOMES OF PERCUTANEOUS CORONARY INTERVENTIONS IN PATIENTS WITH CORONARY ARTERY DISEASE AND CHRONIC KIDNEY DISEASE

Abstract:

Coronary artery disease (CAD) and chronic kidney disease (CKD) are two major conditions frequently encountered in clinical practice, particularly among elderly patients. According to multiple studies, approximately 30–40% of patients with CKD also suffer from CAD, while up to 50% of CAD patients exhibit signs of CKD. CKD significantly increases the risk of developing CAD, especially in advanced stages, where cardiovascular morbidity is 2–4 times higher compared to individuals with normal renal function. Patients with concurrent CAD and CKD often present with increased arterial hypertension, dyslipidemia, systemic inflammation, water-electrolyte imbalance, and elevated liver and kidney enzyme levels. Performing percutaneous coronary intervention (PCI) in such patients requires an integrated approach, taking into account drug interactions, renal protection strategies, and careful monitoring of blood pressure, serum urea, creatinine, and glucose. Despite the clinical importance, there is still a lack of research focused on the impact of CKD on PCI outcomes, particularly in the Uzbek population.