MEGALOBLASTIK ANEMIYA ETIOPATOGENEZIDA VITAMIN B12 TANQISLIGINING RO`LI

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Abstrak:

Ushbu tezisda megaloblastic anemiya rivojlanishida vitamin B12 tanqisligi bilan bog`liq potologik jarayonlar ilmiy asosda yoritiladi. Vitamin B12 DNK sintezi, metilatsiya jarayoni, eritropoez va neyro-metabolik reaksiyalarning asosiy kofaktori sifatida baholandi. Tadqiqotda B12 yetishmovchiligi natijasida timidin sintezi izdan chiqishi, yadro va sitoplazma o‘sishi o‘rtasidagi disproportsiya, suyak ko‘migida samarali bo‘lmagan eritropoez, intramedullyar gemoliz va periferik makrositozning shakllanish jarayonlari ilmiy asosda yoritildi.

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##submission.citations##:

Abdulxamidova D.L., Abdurahmonova H.N., Omonov Sh.R. “Megaloblastik makrositar anemiya”. — TMA repozitoriyasi, 2025. (megaloblastik anemiyaning patogenezi, klinik va diagnostik jihatlari) ([repo.tma.uz][1])

Kurbonova Z.Ch., Babadjanova Sh.A. “Vitamin B12 tanqislik anemiyasi klinik-laborator diagnostikasi va davolash usullari”. Journal of New Century Innovations, 2023. (Vitamin B12 tanqisligi va megaloblastik anemiya to‘g‘risida) ([newjournal.org][2])

Sobirov S.F., Raximberganov S.R., Bekova N.B. “Vitamin B12 defitsit anemiya xavf omili sifatida”. OBRAZOVANIE NAUKA I INNOVATSIYALAR jurnal, 2025. (B12 defitsiti etiopatogenezi haqida) ([scientific-jl.com][3])

Norimov A.Q., Kiyamova D.S. “Inson organizmida B12 vitaminining ahamiyati”. Interdiscipline Innovation and Scientific Research Conference, 2024. (B12 ning hujayra va DNK sinteziga ta’siri) ([interonconf.org][4])

To‘rabek B.T., Saidova G.A. “MIS, B12, B6 yetishmovchiligida rivojlanadigan anemiyalarning biokimyoviy asoslari”. Modern Science and Research, 2025. (B12 defitsitida gemopoez buzilishi) ([InLibrary][5])

Mamatkulova F.X., Xidirov A., Nizomov F. “Jigar kasalliklarida anemik sindrom”. Science and Education, 2025 — B12 bilan bog‘liq anemiya mexanizmlari qisqacha tahlili. ([openscience.uz][6])

(Laboratoriya ishi) “Vitamin B12 tanqislik anemiyasi uchun laboratoriya diagnostikasi”. Respublika sog‘liqni saqlash oliy ta’limi repozitoriyasi, 2025. (DNK sintezi, B12 va folat tanqisligi haqida) ([repository.tma.uz][7])

StatPearls Publishing. “Vitamin B12 Deficiency”. StatPearls [Internet]. — StatPearls Publishing; 2025. (B12 tanqisligining biologik mexanizmi va patogenezi) ([Биотехинфо][8])

“Current Medical Diagnosis & Treatment 2025” – bo‘lim “Vitamin B12 Deficiency”. McGraw-Hill; 2025. (Klinik diagnostika va terapiya bo‘yicha ilmiy tibbiy qo‘llanma) ([AccessMedicine][9])

Pasha S.R. “Evaluation of the Vitamin B12 Deficiency in Megaloblastic Anemia in Tertiary Care Hospital, Lahore”. Journal of Health & Rehabilitation Research, 2024. —([Журнал здоровья][10])