Acute respiratory diseases are the most common among all diseases. Given the variety of symptoms of acute respiratory viral infections, various groups of drugs are used to treat them, however, combined drugs are popular among the population and clinic doctors. This is "Grippomix" - a combined drug containing paracytamol, rimantadine, cetirizine, ascarbic acid, the effectiveness and safety of which was studied in this study. The presence of almost all the necessary active ingredients in a single form used for the complex treatment of acute respiratory viral infections contributed to an increase in patients' compliance with treatment, facilitating the clinical course of the disease, reducing the risk of complications. This helps to reduce the need for antibiotic therapy.