The aim of this study is to analyze the features of development and clinical manifestations of organic emotional lability (OEL) in the post-stroke period, as well as to investigate the relationship between symptom severity, lesion localization, and symptom dynamics. The study involved 80 patients aged 45 to 75 years with ischemic stroke. Assessment tools included the PLACS scale, HADS, MMSE, clinical and neurological examination, and brain MRI data. According to the results, signs of OEL were identified in 60% of patients, predominantly in cases of frontal lobe and basal ganglia lesions. The main symptoms included unmotivated crying, sudden mood swings, and irritability. Patients with OEL showed significantly higher levels of anxiety and depression on the HADS scale (p < 0.01). Over a 30-day period, most patients showed positive symptom dynamics. Thus, organic emotional lability is a common post-stroke complication, and its timely diagnosis and comprehensive therapy contribute to improved rehabilitation outcomes.