Gastrointestinal tract diseases (gastritis, gastric, and duodenal ulcers) are widespread worldwide and have serious socio-economic consequences. This study evaluated the effectiveness of H2 histamine receptor blockers in pharmacotherapy. The clinical status, complaints, laboratory tests, and endoscopic findings of patients were analyzed to assess treatment outcomes. The results demonstrated that H2 blockers effectively reduce gastric acid secretion, accelerate the healing process of ulcers, and alleviate clinical symptoms. The findings confirm the effectiveness of H2 blockers in the treatment of gastrointestinal tract diseases and support their use in rational pharmacotherapy.