The systematization of issues related to clinical symptoms, treatment and prevention of drug allergy is currently of great importance for practical medicine. Knowledge of the clinical manifestations of an allergic reaction to drugs, therapeutic tactics in the relief of its acute phase, organizational and preventive measures can largely reduce the likelihood of adverse outcomes of the disease. According to the Boston Collaborative Drug Surveillance Program, the prevalence of cutaneous adverse drug reactions in hospitalized patients was 2.2%, with antibiotics causing such reactions in 7% of cases.