Modern regenerative therapy is used to treat osteoarthritis of the knee joint. 85 patients treated with OA were followed up, who were divided into 2 groups: 45 patients (52.9%) from group A received 2 PRP injections, while 40 (47.1%) patients from group B received 4 injections. During clinical examination and X-ray examination, all patients were diagnosed with knee osteoarthritis of 2-3 degrees. The results were studied on the VASH scale and the WOMAC index. It was found that PRP injections performed 4 times have the best clinical efficacy.