Reactive arthritis is an aseptic inflammation affecting the joints, occurring simultaneously or following a non-articular infection (such as nasopharyngeal, intestinal, or urogenital infections). It is characterized by asymmetric involvement of the joints, tendons, mucous membranes, skin, nails, lymph nodes, and systemic reactions. Reactive arthritis can appear in both children and adults, with varying clinical manifestations. This clinical case presents a patient diagnosed with reactive arthritis against the background of connective tissue dysplasia, highlighting diagnostic challenges and management approaches in such complex cases.