Despite the use of modern treatments for patients with RA, the incidence of anemia, unwanted complications, and disability in the working population remains very high. The purpose of the study is to improve the principles of proportional treatment, taking into account the structure of anemia in rheumatoid arthritis, its occurrence, and haptoglobin phenotypes. In 2016-2020, a total of 214 patients treated with a diagnosis of rheumatoid arthritis in the cardiorheumatology department of the Samarkand City Medical Association and 20 relatively healthy people as a control group were selected for the study. Examination of patients was carried out using generally accepted clinical, laboratory, and instrumental methods. Changes in iron metabolism parameters are observed in RA patients and are more pronounced in patients with anemia, and such changes depend on the degree of anemia.