Self-nanoemulsifying drug delivery systems (SNEDDS) have emerged as promising platforms for improving the solubility and bioavailability of poorly water-soluble compounds, particularly plant-derived bioactives. In the present study, SNEDDS-based formulations were developed and incorporated into a Carbopol hydrogel and further combined with a non-ionic hydrophilic ointment base to obtain a semi-solid delivery system suitable for topical application.

This study investigates the in vitro antioxidant activity of plant-derived extracts and self-nanoemulsifying drug delivery systems (SNEDDS)-based formulations using the DPPH assay. Oxidative stress is a key factor in the pathogenesis of various diseases, which has led to increased interest in antioxidant-rich formulations. However, many plant-derived bioactive compounds suffer from poor solubility and limited bioavailability, restricting their therapeutic potential.

This study focuses on the development and evaluation of a nanoparticle-based microbeads system as an advanced oral drug delivery platform. Polymer-based microbeads were prepared using ionotropic gelation with sodium alginate as the matrix, incorporating nanoparticles (SNEDDS-based and PLGA-based) to form a hybrid “nano-in-micro” system. The obtained microbeads were evaluated under different ionic strength conditions (0, 50, and 200 mM NaCl) to assess their structural stability and biological performance.