This study examines the effectiveness of simulation centers in medical universities in Uzbekistan, focusing on their role in enhancing practical skills, clinical reasoning, and professional competence among medical students. Simulation centers provide realistic, risk-free environments where learners can practice procedures, manage clinical scenarios, and develop teamwork and communication skills. The research evaluates the integration of simulation-based education into medical curricula, including structured scenarios, feedback mechanisms, and competency assessments. Findings indicate that well-designed simulation centers significantly improve student confidence, skill acquisition, and readiness for clinical practice. The study also highlights challenges, such as technological limitations, faculty training, resource allocation, and curriculum integration. Recommendations for optimizing the effectiveness of simulation centers in Uzbekistan include investment in infrastructure, faculty development, and strategic curriculum planning to align with international standards.