Malignant tumors of the uterus, primarily endometrial cancer (EC), are one of the most common gynecological malignant tumors. The prognosis of uterine cancer and the survival of patients largely depend on the stage of the disease, which is determined based on the results of histological examination and surgical intervention. There are negative prognostic factors that have a statistically significant impact on the long-term treatment outcomes of patients with uterine cancer of clinical stages I-III, including: clinical stage, age, depth of tumor invasion into the myometrium, tumor size and degree of differentiation, the presence of tumor embolism, detection of tumor cell emboli in the blood and lymphatic vessels of the myometrium, in the abdominal cavity, dissemination and lymphogenous metastases. Metastases in the lymph nodes are the most important prognostic factor for early-stage uterine cancer.