The article presents the results of a study of anamnestic, clinical and instrumental-laboratory data and factors from observation of 80 newborns with intrauterine infection and hemolytic disease of moderate and severe severity, who were hospitalized in the neonatal pathology department and the neonatal intensive care unit of the Samarkand Regional Children's Multidisciplinary Medical Center in Samarkand. between 2021 and 2023.