The WHO estimates that TB has claimed the lives of over 1.4 million people in 2019 alone Pulmonary tuberculosis develops in patients with type 2 diabetes mellitus, with moderate to severe severity, subcompensated form and with a complicated course, with more than 9 years of experience of the disease. Patients with diabetes mellitus were characterized by widespreadinfiltrative tuberculosis with bacterial excretion, in every fifth patient with drug-resistant pathogen. The clinical picture of tuberculosis in patients with diabetes mellitus was characterized by severe intoxication and bronchopulmonary syndromes, moderately pronounced changes in the clinical blood test, a pronounced reaction to tuberculin. Pathological reactivity was noted in 2/3 of patients with combined pathology, most of the patients had a low level of adaptation. Despite this, ineffective tuberculosis therapy was noted only in every 4 patients with diabetes mellitus.