This article investigates the role of cultural heritage in fostering tourism development in Karakalpakstan, an autonomous republic located in the northwestern part of Uzbekistan. Using official national statistics, regional tourism data, museum reports, and international tourism analyses, the study examines how key cultural assets—most notably the Savitsky Museum and the archaeological fortresses of Ancient Khorezm—contribute to visitor flows, employment, and regional visibility. The paper further analyzes the economic and social benefits of cultural tourism and identifies structural and environmental constraints limiting sustainable growth, including infrastructural gaps and the long-term consequences of the Aral Sea ecological crisis. Based on empirical data from 2023–2025, the study concludes that while cultural tourism in Karakalpakstan is expanding steadily, strategic investment in infrastructure, professional training, digital branding, and conservation financing is essential to transform cultural heritage into a long-term engine of sustainable regional development.