Nephrotic syndrome (NS) is a chronic renal pathology, classified into steroid sensitive (SSNS) or steroid resistant (SRNS) groups based on response to corticosteroids. Treatment of choice in pediatric NS is always corticosteroid. Steroid resistant nephrotic syndrome in paediatric patients may account for 20 to 30 % of total NS cases and it is significant concern for paediatricians. Steroid resistant cases are difficult to treat and have higher risk of development of end stage renal disease. A case control study was conducted among 48 children suffering from nephrotic syndrome, aged 2–12 years. Among them, 36 patient showed sensitivity to steroid treatment and 12 showed resistance.  Haematological markers (haemoglobin, haematocrit, RBC count) and biochemical markers (albumin, proteinuria , urea , creatinine) were compared.