This paper explores the critical role of women in enhancing innovation infrastructure to spur economic development in Uzbekistan, while addressing both prevailing challenges and strategic approaches. Despite making up a significant portion of the population and workforce, Uzbek women remain underrepresented in sectors critical to innovation and economic growth, particularly in science, technology, engineering, and mathematics (STEM) fields. This study delves into cultural, educational, economic, and professional obstacles that hinder women’s full participation and leadership in innovation. It discusses strategic approaches, including policy reforms, targeted educational programs, support for women entrepreneurs, and the creation of networks and mentorship opportunities aimed at empowering women. Through qualitative analysis and case studies, this research highlights the transformative potential of women in innovation sectors and proposes a multi-stakeholder implementation framework to overcome gender disparities. The findings underscore the necessity of integrating gender inclusivity into national policies to foster a robust innovation ecosystem that can drive sustainable economic development in Uzbekistan.